Ag-catalyzed diastereoselective [6+3] cycloaddition of tropone with homoserine lactone-derived azomethine ylides: synthesis of tricyclic spiropiperidines

作者：Wu, Yang; Liu, Honglei; Zhang, Lei; Sun, Zhanhu; Xiao, Yumei; Huang, Jiaxing; Wang, Min; Guo, Hongchao^*

来源：RSC Advances, 2016, 6(77): 73547-73550.

DOI：10.1039/c6ra14018a

• ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION
• ENANTIOSELECTIVE 3+3 CYCLOADDITION
• DINITROGEN-FUSED HETEROCYCLES
• TETRAHYDRO-BETA-CARBOLINE
• FACILE ACCESS
• PHTHALAZINIUM DICYANOMETHANIDES
• EFFICIENT CONSTRUCTION
• POTENTIAL 1,3-DIPOLES
• PROLINE DERIVATIVES
• PRACTICAL METHOD

Ag-catalyzed [6 + 3] cycloaddition of tropone with homoserine lactone derived azomethine ylides has been developed. The reaction works efficiently under mild conditions to give tricyclic spiropiperidines in moderate to excellent yields with excellent diastereoselectivities.

• 出版日期2016
• 单位中国农业大学