Drugs acting on homeostasis: challenging cancer cell adaptation

作者：Moschovi Maria; Critselis Elena; Cen Osman; Adamaki Maria; Lambrou George I; Chrousos George P; Vlahopoulos Spiros

来源：Expert Review of Anticancer Therapy, 2015, 15(12): 1405-1417.

DOI：10.1586/14737140.2015.1095095

• cell stress
• gene promoter
• homeostasis
• immune system
• metabolism
• signal transduction

Cancer treatment aims to exploit properties that define malignant cells. In recent years, it has become apparent that malignant cells often survive cancer treatment and ensuing cell stress by switching on auxiliary turnover pathways, changing cellular metabolism and, concomitantly, the gene expression profile. The changed profile impacts the material exchange of cancer cells with affected tissues. Herein, we show that pathways of proteostasis and energy generation regulate common transcription factors. Namely, when one pathway of intracellular turnover is blocked, it triggers alternative turnover mechanisms, which induce transcription factor proteins that control expression of cytokines and regulators of apoptosis, cell division, differentiation, metabolism, and response to hormones. We focus on several alternative turnover mechanisms that can be blocked by drugs already used in clinical practice for the treatment of other non-cancer related diseases. We also discuss paradigms on the challenges posed by cancer cell adaptation mechanisms.

• 出版日期2015-12-2
• 单位西北大学