Acylated Oleanane-Type Triterpene Saponins with Acceleration of Gastrointestinal Transit and Inhibitory Effect on Pancreatic Lipase from Flower Buds of Chinese Tea Plant (Camellia sinensis)

作者：Yoshikawa Masayuki^*; Sugimoto Sachiko; Kato Yasuyo; Nakamura Seikou; Wang Tao; Yamashita Chihiro; Matsuda Hisashi

来源：Chemistry and Biodiversity, 2009, 6(6): 903-915.

DOI：10.1002/cbdv.200800153

The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. From the BuOH-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins I, II, and III (1-3, resp), were isolated together with 13 known compound. The chemical structures 1-3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50) = 150 -530 mu M).

• 出版日期2009