Designing an Intracellular Fluorescent Probe for Glutathione: Two Modulation Sites for Selective Signal Transduction

作者:Isik Murat; Guliyev Ruslan; Kolemen Safacan; Altay Yigit; Senturk Berna; Tekinay Turgay; Akkaya Engin U*
来源:Organic Letters, 2014, 16(12): 3260-3263.
DOI:10.1021/ol501272z

摘要

A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.

  • 出版日期2014-6-20