A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

作者：Cho Tae Jun; Kim Jonghoon; Kwon Soon Keun; Oh Keunhee; Lee Jeong ae; Lee Dong Sup; Cho Jaejin^*; Park Seung Bum

来源：Chemical Science, 2012, 3(10): 3071-3075.

DOI：10.1039/c2sc20362f

We discovered a novel small-molecule modulator 5{i,2} that can specifically induce the chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Based on our biochemical and histological studies, 5{i,2} showed more of a directed differentiation of MSCs to chondrocyte balls compared to TGF-beta 3.

• 出版日期2012