A novel Tc-99m labelling strategy for the development of silica based particles for medical applications

作者:Wuillemin Michel A; Stuber Wanda T; Fox Thomas; Reber Michael J; Bruehwiler Dominik; Albertoa Roger; Braband Henrik*
来源:Dalton Transactions, 2014, 43(11): 4260-4263.
DOI:10.1039/c3dt53019a

摘要

The reaction of high-valent fac-{(TcO3)-Tc-99m}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

  • 出版日期2014