Arabinogalactan-type polysaccharides (APS) from Cordyceps militaris grown on germinated soybeans (GSC) induces innate immune activity of THP-1 monocytes through promoting their macrophage differentiation and macrophage activity

作者：Park Dong Ki; Hayashi Toshimitsu; Park Hye Jin^*

来源：Food Science and Biotechnology, 2012, 21(5): 1501-1506.

DOI：10.1007/s10068-012-0199-6

• arabinogalactans-type polysaccharide (APS)
• innate immunity
• phagocytosis
• macrophage differentiation
• THP-1 monocyte

In this study, the immunemodulatory activities of arabinogalactans-type polysaccharide (APS) from Cordyceps militaris grown on germinated soybeans was evaluated in THP-1 human monocytes. The cellular size and the number of intracellular organelles of THP-1 monocytes were increased by APS. Also, APS-treated THP-1 cells significantly developed cellular adherence and macrophagic differentiation to the culture plate surface. APS noticeably enhanced phagocytic activity of THP-1 cells against IgG-FITC-latex beads. APS induced the level of TNF-alpha, IL-12 p40, and IL-8 as well as TLR2 and TLR4 mRNAs. APS can be developed as a promising immunmodulating agent with macrophage-activating properties.

• 出版日期2012-10