Mechanism of action of Salvianolic Acid B by module-based network analysis

作者：Ren, Zhenzhen; Wang, Xing; Wang, Shifeng; Zhai, Chenxi; He, Yusu; Zhang, Yanling^*; Qiao, Yanjiang

来源：Bio-medical Materials and Engineering, 2014, 24(1): 1333-1340.

DOI：10.3233/BME-130936

• Protein interaction network
• module
• mechanism of action
• Salvianolic Acid B
• GO enrichment analysis

Salvianolic Acid B (Sal B) is one of the main medicinal ingredients of Radix Salvia miltiorrhiza (Danshen) and possesses a variety of pharmacological effects. The purpose of this study was to discover the new mechanism of action of Sal B based on the protein interaction network (PIN) analysis. A PIN of Sal B was constructed with 852 nodes and 8,626 interactions. By fast agglomerate algorithm based on the edge clustering coefficients (FAG-EC), 11 modules were detected from the network. Gene ontology (GO) enrichment analysis of the modules demonstrated that the roles of Sal B played in cardiovascular disease were related to multiple biological processes, which could represent the characteristics of Chinese Material Medica (CMM) as a whole to regulate the disease. The most interesting finding of this work was that the anti-inflammatory effect of Sal B was due to the immune response of T lymphocytes by regulating IL-2 family, CD3E, CD79A, MAP3K7 and PRKCQ. Therefore, the module-based network analysis will be an effective method for better understanding CMM.

• 出版日期2014
• 单位北京中医药大学