Autophagy and MHC-restricted antigen presentation

作者：Valecka, Jan; Almeida, Catarina R.; Su, Bing; Pierre, Philippe; Gatti, Evelina^*

来源：Molecular Immunology, 2018, 99: 163-170.

DOI：10.1016/j.molimm.2018.05.009

• Antigen processing
• Dendritic cell
• Autophagy
• MHC
• SQTM1
• Ubiquitin

Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle trafficking, and autophagy, play critical roles in presentation of these antigens. We discuss the role of autophagy, a major intracellular degradation system that delivers cytoplasmic constituents to lysosomes in both MHC class I and II restricted antigen presentation. We propose the new term "Type 2 cross-presentation" (CP2) to define the autophagy-dependent processes leading to MHC II-restricted presentation of intracellular antigens by professional antigen presenting cells. A better understanding of Type 2 cross-presentation may guide future efforts to control the immune system through autophagy manipulation.

• 出版日期2018-7
• 单位上海交通大学