Direct C(sp3)-H functionalization of 2-methylazaarenes using 4-substituted-TEMPO

作者：Zhu, Chuanlei; Li, Hongming; Chu, Changhu^*

来源：Tetrahedron Letters, 2018, 59(51): 4454-4457.

DOI：10.1016/j.tetlet.2018.10.014

• C(sp3)-H Functionalization
• 2-Methylazaarenes
• 4-Substituted-TEMPO
• Azaarene 2-methoxylamines

An efficient and direct C(sp(3))-H functionalization of 2-methyl azaarenes with persistent nitroxide radical 4-substituted-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) under neutral conditions has been developed. A broad of 2-methylazaarenes could be reacted with 4-substituted TEMPOs to afford corresponding azaarene 2-methoxylamines by using cheaper copper (II) acetate hydrate as oxidant.

• 出版日期2018-12-19
• 单位华东理工大学