科研之友
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摘要
Objective: Patients with supracoronary ascending aortic aneurysms can have aortic insufficiency (AI) due to dilatation of the sinotubular junction and/or associated cusp pathology. The incidence and types of cusp lesions as well as the effect of AI severity and cusp repair techniques on outcome in this patient population is not well defined. Methods: Since 1996, 55 patients (mean age: 65 +/- 13 years, 17 bicuspid valves) presented with supracoronary ascending aortic aneurysms and AI that was mild/moderate in 27 (49%) and severe in 28 (51%). Associated pathology included cusp prolapse in 18 (33%), cusp restriction in nine (16%) and both in three (5%). All patients underwent aortic replacement and remodeling of the sinotubular junction. Adjunctive techniques included subcommissural annuloplasty in 38(69%) and cusp repair in 28 (51%). Results: AI severity was not significantly associated with the presence of cusp pathology (p = 0.35). Cusp disease was present in 100% of bicuspid aortic valves compared with only 34% of trileaflet valves (p < 0.001). There was no hospital mortality and overall survival was 94 +/- 4% and 75 +/- 10%, respectively, at 5 and 7 years. Freedom from re-operation was 100% at 7 years and freedom from recurrent AI (>2+) was 87 +/- 7% at 5 years. Neither the presence of preoperative severe AI, nor the need for cusp repair was predictive of late outcome. Conclusions: Cusp pathology is frequently encountered in patients with ascending aortic dilatation and AI. Severe AI is not a contraindication to valve-preserving surgery, but careful identification and repair of cusp pathology, in addition to sinotubular junction reduction, is critical for durable, long-term outcome.
- 出版日期2011-8
