Automated thin-film microextraction coupled to a flow-through cell: somewhere in between passive and active sampling

作者：Wohde Manuel^*; Bartz Jens Ole; Boehm Leonard; Hartwig Christoph; Keil Benjamin Martin; Martin Katharina; Duering Rolf Alexander

来源：Analytical and Bioanalytical Chemistry, 2017, 409(8): 1975-1984.

DOI：10.1007/s00216-016-0145-1

• TFME
• Passive sampling
• Ivermectin
• Iohexol
• Pharmaceuticals
• Xenobiotics

A prototype for the automated thin-film microextraction of pharmaceuticals from aqueous solutions has been developed and is presented here for the first time. With a software-controlled setup, extraction methods for ivermectin and iohexol have been developed. The widely used antiparasitic agent ivermectin is non-polar and has a high tendency to sorb to surfaces. In contrast to this, the nonionic but polar iodinated X-ray contrast agent iohexol is freely water soluble. With these two substances, a wide range of polarity is covered. Sorption kinetics and thermodynamics of ivermectin and iohexol were studied. With the presented passive sampling approach, it was possible to extract up to 96.2% ivermectin with a C-18-phase within 1 h and up to 74.6% of iohexol with a PS-DVB phase within 36 h out of water. Using abamectin as internal standard, it was possible to quantitatively follow dissipation of ivermectin in a simulated surface water experiment. Predominantly, the newly developed prototype can be used for automated and time-resolved extraction of xenobiotics from waterbodies under field conditions, for the extraction of substances under laboratory conditions as an alternative to the elaborate solid-phase extraction, and for the automated control of chemical reaction kinetics.

• 出版日期2017-3