A retrospective study of the efficacy of sofosbuvir plus NS5A inhibitors for patients with hepatitis C virus genotype-2 chronic infection

作者：Lv, Duo-Duo; Wang, Meng-Lan; Chen, En-Qiang^*; Wu, Dong-Bo; Tao, Ya-Chao; Zhang, Dong-Mei; Tang, Hong

来源：European Journal of Gastroenterology and Hepatology, 2019, 31(3): 382-388.

DOI：10.1097/MEG.0000000000001299

• fibrosis
• genotype-2
• hepatitis C virus
• NS5A inhibitor
• sofosbuvir

Background A combination of sofosbuvir (SOF) + NS5A inhibitor therapies is the main treatment for patients with hepatitis C virus (HCV) genotype-2 (GT-2) chronic infection, but the data are rarely reported in China. This study aimed to investigate the virological response and liver fibrosis improvement among GT-2 patients receiving SOF + NS5A inhibitors.
Patients and methods In this retrospective study, patients who received SOF + NS5A inhibitors between March 2016 and July 2017 were recruited. The treatment duration was 12 weeks and the treatment strategies included SOF + daclatasvir, SOF/ledipasvir, and SOF/velpatasvir. The primary endpoint was a sustained virologic response (serum HCV RNA undetectable) at week 12 after the end of therapy and the secondary endpoint was the improvement in liver stiffness and scores of apartate aminotransferase to platelet ratio index and fibrosis-4.
Results A total of 30 GT-2 patients were enrolled, with 13 (43.3%) patients in SOF + daclatasvir, 13 (43.3%) patients in SOF/ledipasvir, and four (13.3%) patients in SOF/velpatasvir. All patients [30/30 (100%)] achieved SVR, irrespective of treatment regimens and degree of liver fibrosis. After the treatment, liver fibrosis scores of apartate aminotransferase to platelet ratio index (2.27 +/- 2.14 vs. 0.89 +/- 0.77, P = 0.003) and fibrosis-4 (1.17 +/- 1.22 vs. 0.42 +/- 0.25, P = 0.013) were both significantly lower than those before treatment.
Conclusion SOF + NS5A inhibitor therapies may induce an excellent virological response and fibrosis improvement in HCV GT-2-infected patients.

• 出版日期2019-3
• 单位四川大学