SMRT epsilon, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors alpha and beta

作者：Mengeling Brenda J; Goodson Michael L; Bourguet William; Privalsky Martin L^*

来源：Molecular and Cellular Endocrinology, 2012, 351(2): 306-316.

DOI：10.1016/j.mce.2012.01.006

• Corepressors
• Nuclear receptors
• Alternative-mRNA splicing
• SMRT
• Retinoic acid receptors
• beta-Strand

The SMRT and NCoR corepressors bind to, and mediate transcriptional repression by, many nuclear receptors. Both SMRT and NCoR are expressed by alternative mRNA splicing, generating a series of structurally and functionally distinct corepressor "variants". We report that a splice variant of SMRT, SMRT epsilon, recognizes a restricted subset of nuclear receptors. Unlike the other corepressor variants characterized. SMRT epsilon possesses only a single receptor interaction domain (RID) and exhibits an unusual specificity for a subset of nuclear receptors that includes the retinoic acid receptors (RARs). The ability of the single RID in SMRT epsilon to efficiently interact with RARs appears to be enhanced by a recently recognized beta-strand/beta-strand interaction between corepressor and receptor. We suggest that alternative mRNA splicing of corepressors can restrict their function to specific nuclear receptor partnerships, and we propose that this may serve to customize the transcriptional repression properties of different cell types for different biological purposes.

• 出版日期2012-4-4