Adsorptive Behavior and Voltammetric Determination of Hydralazine Hydrochloride at A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes

作者：Khodadadian Mehdi^*; Jalili Ronak; Bahrami Mohammad Taher; Bahrami Gholamreza

来源：Iranian Journal of Pharmaceutical Research, 2017, 16(4): 1312-1319.

• Carbon nanotube
• Hydralazine
• Modified electrode
• Adsorption
• Stripping voltammetry

An electroanalytical method has been introduced for highly sensitive determination of hydralazine hydrochloride (Hy-HCl) based on its oxidation at a glassy carbon electrode modified with multiwalled carbon nanotubes (MWCNT/GCE). Studies showed that the electrochemical oxidation of Hy-HCl was accompanied by adsorption and highly sensitive responses could be achieved by adsorptive stripping voltammetry. The electrooxidation of Hy-HCl at MWCNT/GCE occurred at similar to 32 mV which was lower than that observed at bare GCE (similar to 52 mV). The optimum working conditions for determination of the drug using differential-pulse adsorptive stripping voltammetry (DPAdSV) were established. The method exhibited linear responses to Hy-HCl in the concentration range 10-220 nM with a detection limit of 2.7 nM. The proposed method was successfully applied to the determination of this compound in pharmaceutical dosage forms.

• 出版日期2017