A facile synthesis of novel pyrrolo[3,4-b]quinolin-1-one derivatives

作者：Li, Kai; Fu, Xinbo; Zhao, Yanan; Gao, Wentao; Li, Yang^*

来源：Research on Chemical Intermediates, 2016, 42(5): 4273-4287.

DOI：10.1007/s11164-015-2273-1

• Quinoline
• Isoindolin-l-one
• Hybrid
• One-pot synthesis
• Amine

A simple and concise construction of a series of new quinoline-based isoindolin-l-ones, namely N-substituted-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones, wherein the benzene moiety of isoindolin-l-one is replaced by a quinoline ring has been achieved via a two-step procedure, involving the one-step synthesis of ethyl 2-chloromethyl-quinoline-3-carboxylate followed by its one-pot reaction with various amines in a refluxing EtOH-AcOH (v/v, 10:1) solvent system. These newly synthesized compounds could be good candidates for the development of lead compounds for use in medicinal chemistry.

• 出版日期2016-5
• 单位渤海大学