A medical image-based graphical platform-Features, applications and relevance for brachytherapy

作者：Fonseca Gabriel P; Reniers Brigitte; Landry Guillaume; White Shane; Bellezzo Murillo; Antunes Paula C G; de Sales Camila P; Welteman Eduardo; Yoriyaz Helio; Verhaegen Frank^*

来源：Brachytherapy, 2014, 13(6): 632-639.

DOI：10.1016/j.brachy.2014.07.004

• Brachytherapy
• Monte Carlo
• Model-based dose calculation algorithms
• User interface

PURPOSE: Brachytherapy dose calculation is commonly performed using the Task Group-No 43 Report-Updated protocol (TG-43U1) formalism. Recently, a more accurate approach has been proposed that can handle tissue composition, tissue density, body shape, applicator geometry, and dose reporting either in media or water. Some model-based dose calculation algorithms are based on Monte Carlo (MC) simulations. This work presents a software platform capable of processing medical images and treatment plans, and preparing the required input data for MC simulations. %26lt;br%26gt;METHODS AND MATERIALS: The A Medical Image-based Graphical platfOrm Brachytherapy module (AMIGOBrachy) is a user interface, coupled to the MCNP6 MC code, for absorbed dose calculations. The AMIGOBrachy was first validated in water for a high-dose-rate Ir-192 source. Next, dose distributions were validated in uniform phantoms consisting of different materials. Finally, dose distributions were obtained in patient geometries. Results were compared against a treatment planning system including a linear Boltzmann transport equation (LBTE) solver capable of handling nonwater heterogeneities. %26lt;br%26gt;RESULTS: The TG-43U1 source parameters are in good agreement with literature with more than 90% of anisotropy values within 1%. No significant dependence on the tissue composition was observed comparing MC results against an LBTE solver. Clinical cases showed differences up to 25%, when comparing MC results against TG-43U1. About 92% of the voxels exhibited dose differences lower than 2% when comparing MC results against an LBTE solver. %26lt;br%26gt;CONCLUSION: The AMIGOBrachy can improve the accuracy of the TG-43U1 dose calculation by using a more accurate MC dose calculation algorithm. The AMIGOBrachy can be incorporated in clinical practice via a user-friendly graphical interface.

• 出版日期2014-12
• 单位McGill