Poration of lipid bilayers by shock-induced nanobubble collapse

作者：Choubey Amit; Vedadi Mohammad; Nomura Ken ichi; Kalia Rajiv K^*; Nakano Aiichiro; Vashishta Priya

来源：Applied Physics Letters, 2011, 98(2): 023701.

DOI：10.1063/1.3518472

We investigate molecular mechanisms of poration in lipid bilayers due to shock-induced collapse of nanobubbles. Our multimillion-atom molecular dynamics simulations reveal dynamics of nanobubble shrinkage and collapse, leading to the formation and penetration of nanojets into lipid bilayers. The nanojet impact generates shear flow of water on bilayer leaflets and pressure gradients across them, which transiently enhance the bilayer permeability by creating nanopores through which water molecules translocate rapidly across the bilayer. Effects of nanobubble size and temperature on the porosity of lipid bilayers are examined.

• 出版日期2011-1-10