科研之友
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摘要
Objective: Visceral adipose tissue (VAT) is associated with an increased risk of metabolic syndrome (MetS). Recent studies have suggested that VAT negatively affects bone. However, MetS has also been associated with higher estradiol (E-2) levels, which is bone protective. We therefore investigated the impact of VAT and E2 levels on bone density, structural parameters, and strength estimates. Design: Across-sectional studywas conducted in 72 obese men with MetS to investigate the impact of VAT and E-2 levels on bone. Methods: Bone parameters were assessed by dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), and high-resolution peripheral QCT (HRpQCT) at lumbar spine, proximal femur, radius, and tibia. VAT volume was measured by magnetic resonance imaging (MRI) and sexual hormones were measured in blood samples. Results: Men with high VAT had a lower bone density at the hip (P=0.05), lower cortical thickness, and higher buckling ratio at femoral neck (FN) (P=0.008 and P=0.02), compared with men with low VAT, despite a similar body weight and BMI. Generally, E-2 levels were low (median 43 pmol/l), and men with E-2 levels below median had reduced bone density at lumbar spine (p=0.04), and impaired structural parameters at radius and tibia, compared with men with E-2 levels above median. At the hip, VAT volume and E-2 levels affected bone density independently and additively, and 50% of men with high VAT and low E-2 levels had osteopenia with significantly lower T-score at FN (p=0.004). Conclusions: High VAT and low E-2 negatively affect bone in obese men with MetS. VAT and E-2 affect bone density at the hip independently and additively, revealing an unexpected high prevalence of osteopenia in middle-aged men with MetS.
- 出版日期2015-2
