Diffusion Tensor Imaging and Decision Making in Cocaine Dependence

作者：Lane Scott D^*; Steinberg Joel L; Ma Liangsuo; Hasan Khader M; Kramer Larry A; Zuniga Edward A; Narayana Ponnada A; Moeller Frederick Gerard

来源：PLos One, 2010, 5(7): e11591.

DOI：10.1371/journal.pone.0011591

Background: Chronic stimulant abuse is associated with both impairment in decision making and structural abnormalities in brain gray and white matter. Recent data suggest these structural abnormalities may be related to functional impairment in important behavioral processes.
Methodology/Principal Findings: In 15 cocaine-dependent and 18 control subjects, we examined relationships between decision-making performance on the Iowa Gambling Task (IGT) and white matter integrity as measured by diffusion tensor imaging (DTI). Whole brain voxelwise analyses showed that, relative to controls, the cocaine group had lower fractional anisotropy (FA) and higher mean of the second and third eigenvalues (lambda perpendicular to) in frontal and parietal white matter regions and the corpus callosum. Cocaine subjects showed worse performance on the IGT, notably over the last 40 trials. Importantly, FA and lambda perpendicular to values in these regions showed a significant relationship with IGT performance on the last 40 trials.
Conclusions: Compromised white matter integrity in cocaine dependence may be related to functional impairments in decision making.

• 出版日期2010-7-16