Molecular Mechanisms and Function Prediction of Long Noncoding RNA

作者：Ma Handong; Hao Yun; Dong Xinran; Gong Qingtian; Chen Jingqi; Zhang Jifeng; Tian Weidong^*

来源：The Scientific World Journal, 2012, 2012: 541786.

DOI：10.1100/2012/541786

The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.

• 出版日期2012
• 单位复旦大学