Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine derivatives: Synthesis, X-ray structure, magnetism and antiradical activity

作者：Klanicova Alena; Travnicek Zdenek^*; Vanco Jan; Popa Igor; Sindelar Zdenek

来源：Polyhedron, 2010, 29(13): 2582-2589.

DOI：10.1016/j.poly.2010.06.007

• Copper(II)
• N-donor ligands
• Magnetic properties
• Structure elucidation
• Antiradical activity
• SOD-mimics

The reactions of Cu(ClO4)(2)center dot 6H(2)O with 6-(benzylamino)purine derivatives in a stoichiometric 1:2 metal-to-ligand ratio led to the formation of penta-coordinated dinuclear complexes of the formula [Cu(2)(mu-L(1-8))(4)(ClO(4))2](ClO(4))(2).nsolv, where L(1) = 6-(2-fluorobenzylamino)purine (complex 1), L(2) = 6-(3-fluorobenzylamino)purine (2), L(3)= 6-(4-fluorobenzylamino)purine (3), L(4)= 6-(2-chlorobenzylamino)purine (4), L(5) = 6-(3-chlorobenzylamino)purine (5), L(6)=6-(4-chlorobenzylamino)purine (6), L(7)= 6-(3-methoxybenzylamino)purine (7) and L(8)= 6-(4-methoxybenzylamino)purine (8); n = 0-4 and solv = H(2)O, EtOH or MeOH. All the complexes have been fully characterized by elemental analysis, FTIR, UV-Vis and EPR spectroscopy, and by magnetic and conductivity measurements. Variable temperature (80-300 K) magnetic susceptibility data of 1-8 showed the presence of a strong antiferromagnetic exchange interaction between two Cu(II) (S= 1/2) atoms with J ranging from -150.0(1) to -160.3(2)cm(-1). The compound 6 center dot 4EtOH center dot H(2)O was structurally characterized by single crystal X-ray analysis. The Cu center dot center dot center dot Cu separation has been found to be 2.9092(8) angstrom. The antiradical activity of the prepared compounds was tested by in vitro SOD-mimic assay with IC(50) in the range 8.67-41.45 mu M. The results of an in vivo antidiabetic activity assay were inconclusive and the glycaemia in pre-treated animals did not differ significantly from the positive control.

• 出版日期2010-9-3