Absence of Association Between GSTM1 and GSTT1 Polymorphisms and Melanoma Susceptibility: A Meta-Analysis

作者：Nie Fei; Chen Zhixing; Cao Chang; Cen Ying^*

来源：DNA and Cell Biology, 2011, 30(10): 783-788.

DOI：10.1089/dna.2010.1198

Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. The null genotypes GSTM1 and GSTT1 have been implicated in the development of carcinogenesis. We conducted a meta-analysis to examine the association of GSTM1 and GSTT1 homozygous deletion polymorphisms with melanoma risk. In total, 8 relevant studies were identified in searches of the PubMed and Embase databases: 8 investigated GSTM1 (1349 cases and 1560 controls) and 5 GSTT1 (977 cases and 1060 controls). Fixed-and random-effects models were used to assess the summary odds ratios (ORs). No significant association of the GSTM1 and GSTT1 polymorphisms or the GSTM1-GSTT1 interaction on the risk of melanoma was observed (for GSTM1: OR = 1.09; 95% confidence interval, 0.94-1.27; and for GSTT1: OR = 0.95; 95% confidence interval, 0.76-1.19). Similarly, no significant association was found in a subgroup analysis of hair color. These results indicate that the GSTM1 and GSTT1 polymorphisms may not be a risk factor for developing melanoma.

• 出版日期2011-10
• 单位四川大学