ADVERSE REACTION TO IRRIGATION WITH POVIDONE-IODINE AFTER DEEP-IMPACTED, LOWER THIRD MOLAR EXTRACTION

作者：Sammartino G^*; Tia M; Tete S; Perillo L; Trosino O

来源：Journal of Biological Regulators and Homeostatic Agents, 2012, 26(1): 145-149.

• povidone-iodine
• neurotrophic reaction
• dehiscence
• lower third molar
• neurologic damage

Povidone-iodine is most commonly used worldwide because of its germicidal activity, relatively low irritancy or toxicity and low cost. Frequently, povidone-iodine is used as a topical antiseptic for treating and preventing wound infection. In rare cases skin irritation or iododerma-like eruption could represent possible adverse effects due to the oxidative effects of iodine and allergic hypersensitivity reaction. In this report we describe a case of a massive adverse reaction to the irrigation of surgical wound dehiscence with 10% povidone-iodine solution after deep-impacted, lower third molar extraction. This reaction was related to a central neurotrophic reflex involving three trigeminal branches and probably due to a peripheral chemical insult of mandible nerve. This adverse reaction determined a severe edema and diffuse skin lesions, involving the whole left side of the face mimicking an iododerma-like eruption. These violent symptoms were solved after 60 days. Furthermore, we report a small permanent skin scar in the zygomatic area and transient alterations of facial sensitivity on the affected side which completely disappeared in 6 months.

• 出版日期2012-3