科研之友
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摘要
A trial fibrillation (AF) is the most common cardiac arrhythmia in man, and epidemiological study has shown the close relationship between the incidence of AF and aging.(1) Although the effects of aging on atrial electrophysiology have been investigated in humans and animal models,(2-9) the electrophysiological changes that make the atria of aged individuals more susceptible to AF than those of adults remain poorly understood. AF is a reentrant arrhythatia, and the potential importance of dispersion of effective refractory period (ERP) for the induction and maintenance of reentry has long been recognized.(10,11) In this study, we measured the dispersion of ERP and the underlying ionic mechanism in the atria of old and adult canines.
- 出版日期2007-11-20
- 单位中国医学科学院阜外医院; 中国医学科学院北京协和医院
