A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm

作者：de Souza Araujo Isaac Jordao; de Paula Andreia Bolzan; Bruschi Alonso Roberta Caroline; Taparelli Jesus Roberto; Innocentini Mei Lucia Helena; Stipp Rafael Nobrega; Puppin Rontani Regina Maria^*

来源：PLos One, 2018, 13(4): e0195244.

DOI：10.1371/journal.pone.0195244

The use of antimicrobial monomers, linked to the polymer chain of resin composites, is an interesting approach to circumvent the effects of bacteria on the dental and material surfaces. In addition, it can likely reduce the incidence of recurrent caries lesions. The aim of this study was to evaluate the effects of a novel Triclosan Methacrylate (TM) monomer, which was developed and incorporated into an experimental resin composite, on Streptococcus mutans (S. mutans) biofilms, focusing on the analyses of vicR, gtfD, gtfC, covR, and gbpB gene expression, cell viability and biofilm characteristics. The contact time between TM-composite and S. mutans down-regulated the gbpB and covR and up-regulated the gtfC gene expression, reduced cell viability and significantly decreased parameters of the structure and characteristics of S. mutans biofilm virulence. The presence of Triclosan Methacrylate monomer causes harmful effects at molecular and cellular levels in S. mutans, implying a reduction in the virulence of those microorganisms.

• 出版日期2018-4-2