Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells

作者：Xu, Hao; Xu, Yong; Zhang, Wenjie; Shen, Lizong; Yang, Li; Xu, Zekuan^*

来源：Journal of Experimental & Clinical Cancer Research, 2011, 30(1): 86.

DOI：10.1186/1756-9966-30-86

• Aquaporin-3
• Matrix metalloproteinase
• PI3K/AKT pathway

Background: matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis. Aquaporin-3 (AQP3) also plays a critical role in gastric cancer cell migration and proliferation. @@@ Methods: In this study, AQP3 was silenced or over-expressed in SGC7901 cells. @@@ Results: We found a significant decrease in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 knockdown, and a significant increase in MT1-MMP, MMP-2, and MMP-9 expression after AQP3 over-expression in SGC7901 cells. We also found that AQP3 silence led to a significant decrease of phosphorylation of ser473 in AKT in SGC7901 cells. @@@ Conclusion: Our findings showed that AQP3 might positively regulate MMPs proteins expression through PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells.

• 出版日期2011-9-25
• 单位南京医科大学