Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools

作者：Cer Regina Z; Donohue Duncan E; Mudunuri Uma S; Temiz Nuri A; Loss Michael A; Starner Nathan J; Halusa Goran N; Volfovsky Natalia; Yi Ming; Luke Brian T; Bacolla Albino; Collins Jack R; Stephens Robert M^*

来源：Nucleic Acids Research, 2013, 41(D1): D94-D100.

DOI：10.1093/nar/gks955

The non-B DB, available at http://nonb.abcc.ncifcrf.gov, catalogs predicted non-B DNA-forming sequence motifs, including Z-DNA, G-quadruplex, A-phased repeats, inverted repeats, mirror repeats, direct repeats and their corresponding subsets: cruciforms, triplexes and slipped structures, in several genomes. Version 2.0 of the database revises and re-implements the motif discovery algorithms to better align with accepted definitions and thresholds for motifs, expands the non-B DNA-forming motifs coverage by including short tandem repeats and adds key visualization tools to compare motif locations relative to other genomic annotations. Non-B DB v2.0 extends the ability for comparative genomics by including re-annotation of the five organisms reported in non-B DB v1.0, human, chimpanzee, dog, macaque and mouse, and adds seven additional organisms: orangutan, rat, cow, pig, horse, platypus and Arabidopsis thaliana. Additionally, the non-B DB v2.0 provides an overall improved graphical user interface and faster query performance.

• 出版日期2013-1