Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties

作者:Theodorou Ioanna; Anilkumar Parambath; Lelandais Benoit; Clarisse Damien; Doerflinger Anaelle; Gravel Edmond; Duconge Frederic*; Doris Eric
来源:Chemical communications, 2015, 51(80): 14937-14940.
DOI:10.1039/c5cc05333a

摘要

Compact polymerized polydiacetylene-micelles with "stealth'' zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.

  • 出版日期2015
  • 单位中国地震局