A novel small molecule compound possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR7 signaling pathway and alleviates the development of SLE

作者：Gao, Sheng; Yuan, Linbo; Li, Cunyu; Han, Liping; Hua, Chunyan^*

来源：International Immunopharmacology, 2017, 47: 47-52.

DOI：10.1016/j.intimp.2017.03.023

• DCs
• SLE
• TLR7
• FC-99

Dendritic cells (DCs) play an important role in the development and maintenance of immune tolerance. Activation of TLR7, which is expressed in DCs, is thought to contribute to the complex pathophysiology of systemic lupus erythematosus (SLE). In this study, we analyzed the in vitro and in vivo function of a novel small-molecule compound, FC-99, which was previously reported to have immunomodulatory functions. We found that FC-99 inhibited the expression of CD40 and inflammatory mediators (IL-6, IL-12, and CXCL-10), as well as R848-induced phosphorylation of I kappa B-alpha. We also present evidence that FC-99 is remarkably efficacious in the treatment of murine lupus. Interestingly, FC-99 affected the maturation and percentage of DCs in lupus-prone mice. Therefore, FC-99 may serve as a potential drug candidate for treatment of SLE.

• 出版日期2017-6
• 单位温州医科大学; 临沂市人民医院