A novel spirocyclic triterpenoid and a new taraxerane triterpenoid from Teucrium viscidum

作者：Li, Zheng-Yu; Qi, Feng-Ming; Zhi, De-Juan; Hu, Qiao-Ling; Liu, Ying-Hong; Zhang, Zhan-Xin; Fei, Dong-Qing^*

来源：Organic Chemistry Frontiers, 2017, 4(1): 42-46.

DOI：10.1039/c6qo00460a

• TRANSGENIC CAENORHABDITIS-ELEGANS
• NEOCLERODANE DITERPENES
• VAR MIQUELIANUM
• POLIUM
• SESQUITERPENOIDS
• DERIVATIVES
• SYSTEM
• PLANTS

Two new triterpenoids, teuviscins A (1) and B (2), were isolated from the whole plants of Teucrium viscidum. Compound 1 possessed a rare 7(8 -> 9) abeo-9R-D:C-friedo-B':A'-neo-gammacerane skeleton, and compound 2 is a taraxerane triterpene acid. Their structures were characterized by extensive spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and the absolute configurations of 1 and 2 were secured by single-crystal X-ray diffraction analyses using Cu K alpha radiation. Compound 2 showed anti-AD bioactivity which delayed animals paralysis of transgenic AD Caenorhabditis elegans.

• 出版日期2017-1-1
• 单位兰州大学; 功能有机分子化学国家重点实验室