Adipose-Derived Stromal Vascular Fraction Cells and Platelet-Rich Plasma: Basic and Clinical Evaluation for Cell-Based Therapies in Patients With Scars on the Face

作者：Gentile Pietro^*; De Angelis Barbara; Pasin Methap; Cervelli Giulio; Curcio Cristiano B; Floris Micol; Di Pasquali Camilla; Bocchini Ilaria; Balzani Alberto; Nicoli Fabio; Insalaco Chiara; Tati Eleonora; Lucarini Lucilla; Palla Ludovico; Pascali Michele; De Logu Pamela; Di Segni Chiara; Bottini Davide J; Cervelli Valerio

来源：Journal of Craniofacial Surgery, 2014, 25(1): 267-272.

DOI：10.1097/01.scs.0000436746.21031.ba

• Adipose-derived stem cell
• enhanced stromal vascular fraction fat graft with platelet-rich plasma
• platelet-rich plasma

Background: Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae.
Objective: The aim of this article was to describe the preparation and isolation procedures for stromal vascular fraction (SVF), the preparation of platelet-rich plasma (PRP), and the clinical application in the treatment of the scar on the face.
Methods: Ten patients with burns sequelae (n = 6) and post-traumatic scars (n = 4) were treated with SVF-enhanced autologous fat grafts obtained by the Celution System. Another 10 patients with burns sequelae (n = 5) and post-traumatic scars (n = 5) were treated with fat grafting based on the Coleman technique mixed with 0.5 mL of PRP. To assess the effects of their treatment, the authors compared their results with those of a control group consisting of 10 patients treated with centrifuged fat.
Results: In the patients treated with SVF-enhanced autologous fat grafts, we observed a 63% maintenance of contour restoring after 1 year compared with only 39% of the control group (n = 10) treated with centrifuged fat graft (P < 0.0001). In the patients treated with fat grafting and PRP, we observed a 69% maintenance of contour restoring after 1 year compared with that of the control group (n = 10).
Conclusions: Autologous fat grafting is a good method for the correction of scars on the face instead of the traditional scar surgical excision.

• 出版日期2014-1