A novel near-infrared fluorescent platform with good photostability and the application for a reaction-based Cu2+ probe in living cells

作者：Liu, Keyin; Shang, Huiming; Meng, Fangfang; Liu, Yong; Lin, Weiying^*

来源：Talanta, 2016, 147: 193-198.

DOI：10.1016/j.talanta.2015.09.052

• Near-infrared fluorescence
• Photostability
• Reaction-based probe
• Cu2+ ion
• Cell imaging

Most of the near-infrared (NIR) fluorescent copper ion probes are coordination-based, and the fluorescence enhancement is between 10 and 20 folds. Herein, a novel NIR fluorescent dye named CSCN with excellent photostability and a reaction-based Cu2+ NIR probe named CSCN-Cu were reported. CSCN exhibited good photostability toward photo irradiation. CSCN-Cu showed lower background fluorescent interference and over 40-fold fluorescence enhancement in NIR region, it also exhibited good selectivity toward Cu2+ in Hepes solution. Biotic experiments demonstrated that CSCN-Cu possessed low toxicity and successfully imaged Cu2+ in living cells under the conditions performed.

• 出版日期2016-1-15
• 单位济南大学