Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

作者：Guo, Yi; Fang, Jing; Liu, Yan; Sheng, Hai-Hui; Zhang, Xiao-Yan; Chai, Hai-Na; Jin, Wei; Zhang, Ke-Hao; Yang, Chang-Qing; Gao, Heng-Jun^*

来源：World Journal of Gastroenterology, 2011, 17(13): 1759-1765.

DOI：10.3748/wjg.v17.i13.1759

• Gastric cancer
• Genetic susceptibility
• Single nucleotide polymorphism
• MYC
• 8q24

AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. @@@ METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. @@@ RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). @@@ CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.

• 出版日期2011-4-7
• 单位同济大学; 上海市闵行区中心医院; 上海交通大学