Association Between the SNP rs143383+104T/C in the GDF5 Gene and the Risk of Knee Osteoarthritis in a Population from Northern Mexico-A Case-Control Study

作者：Garcia Alvarado Francisco; Rosales Gonzalez Manuel; Arellano Perez Vertti Daniel; Espino Silva Perla; Meza Velazquez Maria; Ruiz Flores Pablo^*

来源：Genetic Testing and Molecular Biomarkers, 2018, 22(8): 503-506.

DOI：10.1089/gtmb.2018.0142

• knee osteoarthritis
• SNP rs143383+104T/C
• GDF5 gene

Background: Previous studies have found an association between the SNP rs143383 + 104T/C in the growth differentiation factor 5 (GDF5) gene and the risk of developing knee osteoarthritis (KOA) in various populations worldwide.
Objective: To discover if there is an association between the SNP rs143383 + 104T/C, in the GDF5 gene and the risk of developing KOA in individuals from northern Mexico.
Methods: We used a case-control study format that included 145 patients with KOA and 145 healthy controls unrelated to patients. A peripheral blood sample was taken for each of them to identify the SNP by means of real-time PCR according to standard protocols.
Results: We found a strong association between the TT genotype and the risk of developing KOA (OR = 1.7, 95% CI = 1.12-2.8, p = 0.014), but not in the heterozygous TC state (OR = 1.56, CI 95% = 0.58-4.17, p = 0.367).
Conclusion: The TT genotype of the SNP rs143383 increases the susceptibility to KOA in the population of northern Mexico, according to the recessive segregation model.

• 出版日期2018-8