Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity

作者：Jimenez Romero Carlos; Mayer Alejandro M S; Rodriguez Abimael D^*

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(1): 344-348.

DOI：10.1016/j.bmcl.2013.11.008

• Aplysia dactylomela
• Diterpene
• Prenylbisabolane
• anti-Neuroinflammatory activity
• Tuberculosis

A new regular diterpene possessing an unusual 1,6-anti-3-methylcyclohex-2-en-1-ol ring system, dactyloditerpenol acetate (1), has been extracted from the tropical sea hare Aplysia dactylomela and its stereostructure elucidated by spectroscopic methods. The absolute configuration of 1 was determined as 1S, 6S, 7R, 10S, and 11R by application of Kishi's method for the assignment of absolute configuration of alcohols. The new diterpene potently inhibited in vitro thromboxane B-2 (TXB2) (IC50 0.4 mu M) and superoxide anion (O-2(-)) (IC50 1 mu M) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia, with concomitant low short-term toxicity.

• 出版日期2014-1-1