Age-Based Reference Ranges for Annual Height Velocity in US Children

作者：Kelly Andrea; Winer Karen K; Kalkwarf Heidi; Oberfield Sharon E; Lappe Joan; Gilsanz Vicente; Zemel Babette S^*

来源：JOURNAL OF CLINICAL ENDOCRINOLOGY %26 METABOLISM, 2014, 99(6): 2104-2112.

DOI：10.1210/jc.2013-4455

Objective: Clinicians caring for children rely on measures of linear growth as a biomarker of development and overall health. Current reference ranges for height velocity (HV) for US children are unable to provide HV percentiles or Z-scores for early maturing and late maturing children at ages other than age at peak velocity. We present empirically acquired, age-specific reference ranges for HV from a contemporary sample of US youth. %26lt;br%26gt;Study Design: Subjects were enrolled in the Bone Mineral Density in Childhood Study, a large, multicenter, multiethnic, contemporary cohort of children (aged 5-19 y at enrollment) from the United States followed for up to 7 years. More than 4000 annual (12 +/- 1 mo) HV measurements from approximately 1500 children were available. Pubertal status was determined by breast stage or testicular volume assessed by experienced health providers. Age-specific reference ranges were determined using the LMS method. %26lt;br%26gt;Results: Reference ranges (third to 97th percentiles) were generated for the entire cohort and for subgroups whose pubertal timing was defined as %26quot;earlier,%26quot; %26quot;average,%26quot; or %26quot;later.%26quot; African American girls experienced earlier pubertal onset and had greater HV at younger ages and lower HV at older ages, compared to non-African American girls; differences did not persist after adjustment for pubertal timing. These differences were not observed for males. %26lt;br%26gt;Conclusions: These reference ranges for annual HV can be used to assess growth relative to peers of the same age and sex, with consideration of pubertal timing. Z-scores and exact percentiles for HV can also be determined for population studies.

• 出版日期2014-6