Petchiethers A and B, novel meroterpenoids with a 14-or 15-membered ring from Ganoderma petchii

作者：Li, Cheng-Gang; Luo, Qi; Guo, Ping-Xia; Chen, Li-Li; Cheng, Yong-Xian^*

来源：Phytochemistry Letters, 2016, 18: 14-18.

DOI：10.1016/j.phytol.2016.08.013

• Meroterpenoids
• Petchiether A
• Petchiether B
• Absolute configuration

Petchiethers A (1) and B (2), two novel meroterpenoids respectively with a 14- or 15-membered ring were isolated from the fruiting bodies of Ganoderma petchii. Their structures were identified by spectroscopic data. The absolute configurations of compounds 1 and 2 were assigned by computational methods. In particular, the stereochemistry of 1 was further confirmed by the Mosher's method. The inhibitory effects of compounds 1 and 2 on fibronectin secretion were evaluated by using the ELISA technique in TGF-beta 1-induced rat kidney tubular epithelial cells. The results show that these substances could inhibit fibronectin production in a dose-dependent manner, indicating their potential on kidney protection.

• 出版日期2016-12
• 单位中国科学院大学; 大理大学; 中国科学院昆明植物研究所