Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis

作者：Zhang, W.; Zhang, L. C.; Chen, H.; Tang, P. F.^*; Zhang, L. H.

来源：Genetics and Molecular Research, 2015, 14(3): 7655-7660.

DOI：10.4238/2015.July.13.10

• Insulin-like growth factors
• Osteoporosis
• Polymorphism

We conducted a case-control study to assess the relationship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to have drinking and smoking habits and have lower bone mineral density in the L-2-L-4 vertebrae, femoral neck, and total hip. According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97). In conclusion, our results suggest that the TT genotype of IGF-I rs35767 was associated with an increased risk of osteoporosis, suggesting that this polymorphism can be used as a predictive factor for osteoporosis risk.

• 出版日期2015
• 单位中国人民解放军总医院