Analysis of factors associated with changes in the oral glucose tolerance test, regardless of the values of fasting glucose

作者：Lauria Marcio Weissheimer^*; Bastos Dias Isabela Nacif; Sarquis Soares Maria Marta; Cordeiro Giovana Vignoli; Barbosa Victor Euripedes; Ramos Adauto Versiani

来源：Arquivos Brasileiros de Endocrinologia e Metabologia, 2011, 55(9): 708-713.

• Diabetes mellitus
• impaired glucose tolerance
• oral glucose tolerance test
• impaired fasting glucose

Objective: To identify factors associated with changes in oral glucose tolerance test (OGTT), regardless of fasting glucose (FG). Subjects and methods 377 patients (53.8 +/- 15.2 years, 77.7% women and BMI = 31.4 +/- 5.9 kg/m(2)) with no history of diabetes mellitus (DM), underwent OGTT and compared according to the results: normal (NGT), impaired (IGT) and DM. Results: 202 patients (53.6%) had altered glucose tolerance: 69 with DM (18.3%) and 133 with IGT (35.3%). In multivariate analysis, factors regardless of FG that were associated (P < 0.05) with changes in the OGTT were age (DM = 58.7 +/- 12.9; IGT = 56.7 +/- 14.3; NGT = 49.6 +/- 15.6 years), hypertension (DM = 69.6%; IGT = 63.9%; NGT = 43.4%), FG (DM = 111.9 +/- 9.2; IGT = 103.5 +/- 10.3; NGT = 96.6 +/- 11.1 mg/dL), HbA1C (DM = 6.1 +/- 0.7%; IGT = 6.1 +/- 0.5%; NGT = 5.8 +/- 0.4%), triglycerides (DM = 179.3 +/- 169.9; IGT = 154.2 +/- 84.1; NGT = 129.1 +/- 71.9 mg/dL), HDL-c (DM = 44.7 +/- 9.2; IGT = 47.5 +/- 12.3; NGT = 50.6 +/- 13.4 mg/dL) and uric acid in women (DM = 5.3 +/- 1.5; IGT = 5.3 +/- 1.3; NGT = 4.7 +/- 1.3 mg/dL). Conclusion: Age, hypertension, elevated triglycerides, HbA1C, uric acid (in women) and low HDL-C are associated with changes in the OGTT patients with overweight / obesity, irrespective of FG. Arq Bras Endocrinol Metab. 2011;55(9):708-13

• 出版日期2011-12