BODIPY based %26apos;click on%26apos; fluorogenic dyes: application in live cell imaging

作者：Chauhan Dinesh Pratapsinh; Saha Tanmoy; Lahiri Mayurika; Talukdar Pinaki^*

来源：Tetrahedron Letters, 2014, 55(1): 244-247.

DOI：10.1016/j.tetlet.2013.11.003

• BODIPY
• Azide-alkyne click reaction
• Fluorescence
• Solvatochromic properties
• Cell imaging

The design, synthesis, and photophysical properties of new BODIPY-based fluorogenic %26apos;click on%26apos; dyes are reported. CuAAC reaction of non-fluorescent BODIPY azide with a series of non-fluorescent alkyne molecules resulted in fluorescent triazoles which displayed up to 532-fold enhancement of fluorescence in the red region. Imaging studies confirmed the general trend of cell permeability and a cholesterol linked derivative exhibited selective localization into intracellular membranes.

• 出版日期2014-1-1