Antiplasmodial and Cytotoxic Dibenzofurans from Preussia sp harboured in Enantia chlorantha Oliv

作者：Talontsi Ferdinand Mouafo; Lamshoeft Marc; Douanla Meli Clovis; Kouam Simeon Fogue; Spiteller Michael^*

来源：Fitoterapia, 2014, 93: 233-238.

DOI：10.1016/j.fitote.2014.01.003

• Enanthia chloranta Oliv
• Endophyte
• Dibenzofurans
• Antiplasmodial activity
• Cytotoxicity
• Preussia sp.

Two unusual dibenzofurans, preussiafurans A-B (1-2), together with six known compounds have been isolated from the fungus Preussia sp. occurring in Enantia chlorantha Oliv. The structures were established on the basis of 1D and 20 NMR spectroscopy and MS analysis. Compounds 1-4 showed antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum (NF54) and moderate cytotoxicity on L6 cell lines with IC50 values of 8.67 and 14.8 mu M, respectively.

• 出版日期2014-3