Appearance of reassortant European avian-origin H1 influenza A viruses of swine in Vietnam

作者：Takemae N; Nguyen P T; Le V T; Nguyen T N; To T L; Nguyen T D; Pham V P; Vo H V; Le Q V T; Do H T; Nguyen D T; Uchida Y; Saito T^*

来源：Transboundary and Emerging Diseases, 2018, 65(4): 1110-1116.

DOI：10.1111/tbed.12849

• European influenza A virus of swine
• influenza A virus
• pig
• Vietnam

Three subtypesH1N1, H1N2 and H3N2of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark. In addition, the internal genes of these Vietnamese isolates were derived from human A(H1N1)pdm09 viruses, suggesting that the Vietnamese H1N2 IAVs-S are reassortants between European H1N2 IAVs-S and human A(H1N1)pdm09v. The appearance of European avian-like H1N2 IAVs-S in Vietnam marks their first transmission outside Europe. Our results and statistical analyses of the number of live pigs imported into Vietnam suggest that the European avian-like H1N2 IAVs-S may have been introduced into Vietnam with their hosts through international trade. These findings highlight the importance of quarantining imported pigs to impede the introduction of new IAVs-S.

• 出版日期2018-8