Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats

作者：Navarrett Scott; Collier Lauren; Cardozo Christopher; Dracheva Stella^*

来源：Neuroscience Letters, 2012, 506(1): 74-78.

DOI：10.1016/j.neulet.2011.10.052

• Rat
• SCI
• 5-HT2(A)R
• 5-HT2(c)R
• mRNA editing

Recent studies reported that a recovery of motoneurons after spinal cord transection at the sacrocaudal level may depend on adaptive alterations of the serotonin 2C (5-HT2cR) and 2A (5-HT2cR) receptor function via changes in mRNA editing or protein expression, respectively. It has been suggested that depletion of serotonergic input may drive these adaptations. Here, mRNA editing and/or expression of 5-HT2cR and 5-HT2AR was evaluated in rats that sustained a complete transection at the thoracic (T10) level. While 5-HT2AR mRNA expression was upregulated below the site of spinal cord injury (SCI), no changes in 5-HT2cR mRNA editing or expression were detected. These findings argue against the hypothesis that 5-HT2cR editing is regulated by extracellular serotonin levels. Rather, it appears that the editing process is just one of the ways in which excitability of motor neurons can be restored following SCI. To this end, the influence of excitatory locomotor circuits on motor neurons in the thoracic spinal cord of rats requires further exploration. Published by Elsevier Ireland Ltd.

• 出版日期2012-1-6