科研之友
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摘要
Although the molecular details remain unclear, Writ signaling via both canonical and noncanonical pathways is integral to cardiac specification and morphogenesis. A growing body of evidence also suggests substantial overlap between these supposedly discrete pathways in cell- and context-dependent manners. The ability of Wnt11 to induce cardiomyogenesis both during embryonic development and in adult cells makes it an attractive candidate for preprogramming cells for cardiac repair This review primarily discusses various aspects of noncanonical Writ signaling in cardiogenesis with particular emphasis on Wnt11.
- 出版日期2008-10
