Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT and F-18 FDG PET/CT in patients with rectal cancer

作者：Rendl Gundula^*; Rettenbacher Lukas; Holzmannhofer Johannes; Datz Lidwina; Hauser Kronberger Cornelia; Fastner Gerd; Oefner Dietmar; Sedlmayer Felix; Pirich Christian

来源：Annals of Nuclear Medicine, 2015, 29(3): 284-294.

DOI：10.1007/s12149-014-0938-2

• 18F-FDG
• 18F-FLT
• PET/CT
• Rectal cancer
• Radiochemotherapy

Objective The comparison of 2-deoxy-2-[18F] fluoro-D-glucose (F-18 FDG) and 3'-deoxy-3'-[18F] fluorothymidine (F-18 FLT) imaging in patients with rectal cancer before and after neoadjuvant radiochemotherapy (RCT) in relation to histopathology and immunohistochemistry obtained from surgery.
Methods 20 consecutive patients (15 m, 5 f), mean age of 65 +/- 10 years were included into this prospective study with a mean follow-up of 4.1 +/- 0.8 years.
Results Among histopathological responders (n = 8 out of 20), posttreatment F-18 FLT and F-18 FDG scans were negative in 75 % (n = 6) and 38 % (n = 3), respectively. The mean response index (RI) was 61.0 % +/- 14.0 % for F-18 FLT and 58.7 % +/- 14.6 % for F-18 FDG imaging. Peritumoral lymphocytic infiltration (CD3 positive cells) was significantly related to posttreatment SUVmax in F-18 FDG but not F-18 FLT studies.
Conclusion A significant decrease of SUVmax in F-18 FDG and F-18 FLT studies could be seen after RCT. Negative posttreatment F-18 FLT studies identified more histopathological responders.

• 出版日期2015-4