Antiepileptic drugs and vitamin B6 plasma levels in adult patients

作者：Linnebank Michael^*; Moskau Susanna; Semmler Alexander; Widman Guido; Weller Michael; Kallweit Ulf; Elger Christian E

来源：Epilepsy Research, 2012, 101(1-2): 182-184.

DOI：10.1016/j.eplepsyres.2012.03.002

• Antiepileptic drugs
• Vitamin B6

Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n = 385), untreated (n = 15) and healthy controls (n = 233). The mean plasma vitamin B6 levels of the AED-treated (12.1 +/- 10.1; p = 0.093) and the untreated patients (15.6 +/- 12.4; p = 0.664) were not significantly different from the controls (13.9 +/- 15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment.

• 出版日期2012-8