A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents

作者：Rajanarendar E^*; Thirupathaiah K; Ramakrishna S; Nagaraju D

来源：Chinese Chemical Letters, 2015, 26(12): 1511-1513.

DOI：10.1016/j.cclet.2015.07.024

• Imidazo[1,2-b]isoxazoles
• 2-Amines
• Mannich bases

A series of novel imidazo[1,2-b]isoxazoles 3 and their Mannich bases 4-6 were synthesized via convenient reactions. The reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-aryl imidazo[1,2-b]isoxazoles 3 in good yields. Compounds 3 on treatment with 37% formaline and secondary amines furnished the corresponding novel Mannich bases viz., 6-methyl-3-aryl-2-(morpholine/pyrrolidin-1-yl/piperidin-1-yl)-methyl-imidazo[1,2-b]isoxazoles 4-6.

• 出版日期2015-12