Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection

作者：Meseda Clement A; Srinivasan Kumar; Wise Jasen; Catalano Jennifer; Yamada Kenneth M; Dhawan Subhash^*

来源：Biochemical and Biophysical Research Communications, 2014, 454(1): 84-88.

DOI：10.1016/j.bbrc.2014.10.035

• Vaccinia
• Non-coding RNAs
• Heme oxygenase-1
• Host defense
• Gene expression

Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. Although the functions of many snRNAs remain undetermined, a population of snRNAs is produced during the early phase of infection of cells by vaccinia virus. In the present study, we demonstrate a direct correlation between expression of the cytoprotective enzyme heme oxygenase-1 (HO-1), suppression of selective snRNA expression, and inhibition of vaccinia virus infection of macrophages. Hemin induced HO-1 expression, completely reversed virus-induced host snRNA expression, and suppressed vaccinia virus infection. This involvement of specific virus-induced snRNAs and associated gene clusters suggests a novel HO-1-dependent host-defense pathway in poxvirus infection. Published by Elsevier Inc.

• 出版日期2014-11-7
• 单位NIH