Paroxysmal Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome in Ankylosing Spondylitis: A Large Cohort Observation Study and Literature Review

作者：Ho Huei Huang; Yeh San Jou; Tsai Wen Pin; Wang Chin Man; Chen Ji Yih^*

来源：Seminars in Arthritis and Rheumatism, 2012, 42(3): 246-253.

DOI：10.1016/j.semarthrit.2012.04.002

• ankylosing spondylitis
• paroxysmal supraventricular tachycardia
• atrioventricular reentry
• Wolff-Parkinson-White syndrome
• ventricular preexcitation

Objectives: To investigate the associations of paroxysmal supraventricular tachycardia (PSVT) and Wolff-Parkinson-White (WPW) syndrome with ankylosing spondylitis (AS). %26lt;br%26gt;Methods: We conducted a retrospective cohort study by reviewing the medical records of 1503 consecutive AS patients diagnosed at a tertiary medical center. The clinical and electrocardio-graphic (ECG) characteristics of 641 AS patients having 12-lead ECG available were further analyzed in a precise manner. %26lt;br%26gt;Results: Among the 641 AS patients with 12-lead ECG available for detecting cardiac abnormalities, 14 were identified as having PSVT, including 3 with WPW syndrome and 1 having a WPW (ventricular preexcitation) ECG pattern. A higher proportion of AS patients presented with PSVT (21.8/1000) compared with a general population-based study (2.25/1000). Also, AS patients demonstrated a higher prevalence of WPW syndrome or WPW pattern (6.24/1000) than found in general population-based studies (0.9 to 1.5/1000). Ankylosing spondylitis patients with PSVT or WPW syndrome had significantly higher rates of peripheral arthritis (78.6%; P = 0.002), acute anterior uveitis (64.3%; P = 0.003), bamboo spine (64.3%; P = 0.001), and other cardiovascular disorders (85.7%; P %26lt; 0.0001) than the remaining 627 patients without PSVT. %26lt;br%26gt;Conclusions: Ankylosing spondylitis patients had a high probability of developing PSVT and WPW syndrome. Detailed ECG and electrophysiological examinations are required for early detection of PSVT and WPW syndrome for prompt resolution of potentially life-threatening complications in all AS patients, especially those presenting with the symptoms of palpitation, dizziness, dyspnea, or syncope.

• 出版日期2012-12
• 单位长春大学